Icthyosis / fish scale disease / collodion baby. It is a genetics- autosomal recessive disorder, Affecting around 1 in 600,000 people due to deficiency of the enzyme keratinocyte transglutaminase- Keratinization disorders (hyperkeratosis). Synonane of Collodion baby. a. Fish scale disease. b. collodion baby. Cause of Collodion baby. Genetics- autosomal recessive disorder. Affecting around 1 in 600,000 people. Basic defect- deficiency of the enzyme keratinocyte transglutaminase- Keratinization disorders (hyperkeratosis). Clinical feature of Collodion baby. - Scanty hair (may be absent). - Ectropion (lower eyelids turned outwards away from the eyeball). - Flat nose or ear. - Eclabium-(O shaped oral orifice)- the turning out of the lips due to the tightness of the membrane. - Extensive scaling of the skin caused by hyperkeratosis. - Very hard, thick, scaly, parchment like skin. - Dry fissur...